The Preparation and Pharmacological Screenings of 2-Substituted Phenethyl-3-[(N, N-dialkyl, or N-cycloalkyl) aminocarbonylethyl]-amino-6-methylpyridine
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ATTEMPTED PREPARATION OF N-SUBSTITUTED DIPHENYLCYCLOPROPENEIMINE N-OXIDE
The reaction of diphenylcyclopropenone with several N-substituted hydroxylamine and primary amines are investigated. Most of these reactions led to ring opened or ring enlarged products, instead of the desired N-Oxide or imine. The reaction of cyclopropeneimine with peracid-another possible route to N-substituted cyclopropeneimine N-Oxide is studied. Most of the unexpected products are ide...
متن کاملFlexible cycloalkyl-substituted N-heterocyclic carbenes.
The use of two metal systems cis-Pt(NHC)(2)Me(2) and cis-Ir(NHC)(CO)(2)Cl help to highlight the flexibility of a series of cycloalkyl-substituted N-heterocyclic carbene ligands (ICy, ICy(7), ICy(8), ICy(12)). Bond dissociation enthalpies of several N-heterocyclic carbenes (NHCs) in cis-Pt(NHC)(2)Me(2) are estimated. Electronic and steric parameters of the ICy(n) ligands are quantified and discu...
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A facile synthesis of 2-amino-1,3-oxazoles via CuI -catalyzed oxidative cyclization of enamines and N,N-dialkyl formamides has been developed. The reaction proceeds through an oxidative C-N bond formation, followed by an intramolecular C(sp2 )-H bond functionalization/C-O cyclization in one pot. This protocol provides direct access to useful 2-amino-1,3-oxazoles and features protecting-group-fr...
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Although the mol-ecular structure of the title compound, C22H32N4O8, displays a twofold symmetry of the mol-ecule including the meth-oxy and methyl substituents, no crystallographic twofold symmetry is observed in the X-ray structure analysis. The carbonyl O atoms alternately point to different sides of the plane defined by the carbonyl C atoms. Two meth-oxy groups are oriented inside the mol-e...
متن کاملPREPARATION AND MOLECULAR STRUCTURE OF TRlS[(N, N, N\' , N\' - DIAMINE) L1TI-IIUMj TETRAMETHYLETHYLENE HEXAMETHYLSAMARATE(III), {[Li(TMEDA)b [Sm(CH3)6]}.THF
Inc Sm(1)(TIIFh reacts with mcthylllthlUm In TIIF In the prese nce of lclram c lhyt c lhy lcn c d lamln e, TMEDA , 10 gIve 1[1 .J(l ·MI :I)A)h[Sm«('I I)61}. J'IIF. Tl1c complex has been ch;lractcnzcd hy elemenl al analyses, lit spectrum and magnetic mcasurem ent . Molecular .lOd clymsl .SruClUrc of thl! complcx hoo been determmed by a sIngle cryst .. ! X - ray diffractIOn . The crystalS ar...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1971
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.91.8_787